Cause of Colon Cancer Points Right to Your MOUTH

Written by Alex Reid
Posted October 1, 2019

How healthy is your mouth? Tooth decay may be a far more significant issue than bad breath, discolored teeth, and periodontal disease. 

According to a recent study published in EMBO Reports, a particular gut microbe is linked to both tooth decay and colon cancer.

Today, colon cancer is the second leading cause of cancer-related death in the United States. It’s also the second most prevalent cancer in the entire world. 

Colon cancer develops because of tumor mutations and certain microbes. 

If you have severe tooth decay, it could be a sign that you have an overgrowth of a type of oral bacteria that accelerates the growth of cancer cells. 

Dr. Yiping Han, one of the researchers of this study, reported that it could be more challenging to treat people for colon cancer if they have oral health issues. 

This could be one reason some cases escalate far more quickly than others…

Han and his team previously discovered the bacteria Fusobacterium nucleatum, which is a key microbe in the creation of dental plaque. 

One-third of colon cancers are linked to F. nucleatum. 

And get this: 

The cases of colon cancer associated with this type of bacteria are far more aggressive than others.

They believe this is due to the fact that F. nucleatum produces a molecule called FadA adhesin. 

FadA adhesin is linked to several colorectal cancers because of its ability to trigger a signaling pathway in colon cells. It only promotes the growth of cancer cells and not healthy cells. 

The researchers found that the reason F. nucleatum only interacts with cancer cells is that healthy colon cells don’t have a protein called Annexin A1. 

Annexin A1 is what allows F. nucleatum to bind to cancer cells. They confirmed these findings by performing lab tests using mice. 

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Han added:

We propose a two-hit model, where genetic mutations are the first hit. F. nucleatum serves as the second hit, accelerating the cancer signaling pathway and speeding tumor growth.

They also examined RNA-sequencing data from National Center for Biotechnology Information, which contained information on 466 colon cancer patients. Those with increased Annexin A1 expression had a worse prognosis, regardless of a patient’s age, gender, or cancer grade and stage. 

Han and his team are now seeking ways to use this knowledge for colon cancer treatment and prevention. 

Interestingly, an unrelated study in the journal Scientific Reports discovered that there are ways to inhibit the growth of F. nucleatum. 

Certain compounds in both green and black tea can help prevent the bacteria from growing and reduce its dangerous properties.

Tea extracts also act as antibacterial agents against F. nucleatum. 

Drinking tea and using extracts could potentially be used to treat periodontal disease as well as reduce the aggressiveness of some colon cancers.

More research needs to be done to confirm this. In the meantime, there’s no harm in staying on the safe side and enjoying a cup of tea. 

To your health,

Alex Reid
President, Clear Health Now


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